ParkinsonFranceV1, Main, Exploration, bibRecord, 000C81

Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation Into a Rat Model of Amyotrophic Lateral Sclerosis

Identifieur interne : 000C81 ( Main/Exploration ); précédent : 000C80; suivant : 000C82

Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation Into a Rat Model of Amyotrophic Lateral Sclerosis

Auteurs : Iuliana Ristea Popescu [Belgique] ; Charles Nicaise [Belgique] ; Song Liu [France] ; Grégoire Bisch [France] ; Sarah Knippenberg [Allemagne] ; Valery Daubie [Belgique] ; Delphine Bohl [France] ; Roland Pochet [Belgique]

Source :

Stem Cells Translational Medicine [ 2157-6564 ] ; 2013.

RBID : PMC:3659761

Abstract

This study analyzed the fate of human induced pluripotent stem cell (iPSC)-derived neural progenitors transplanted into the spinal cord of wild-type and transgenic rats carrying a human mutated SOD1(G93A) gene. Results demonstrate proof-of-principle of survival and differentiation of human iPSC-derived neural progenitors in in vivo amyotrophic lateral sclerosis (ALS) environment, offering perspectives for the use of iPSC-based therapy in ALS.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659761

DOI: 10.5966/sctm.2012-0042
PubMed: 23413376
PubMed Central: 3659761

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>This study analyzed the fate of human induced pluripotent stem cell (iPSC)-derived neural progenitors transplanted into the spinal cord of wild-type and transgenic rats carrying a human mutated SOD1(G93A) gene. Results demonstrate proof-of-principle of survival and differentiation of human iPSC-derived neural progenitors in in vivo amyotrophic lateral sclerosis (ALS) environment, offering perspectives for the use of iPSC-based therapy in ALS.</p>
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La maladie de Parkinson en France (serveur d'exploration)

Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation Into a Rat Model of Amyotrophic Lateral Sclerosis

Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation Into a Rat Model of Amyotrophic Lateral Sclerosis

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Abstract

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